Notch-Delta signaling is a fundamental cell-cell communication mechanism that governs the differentiation of many cell types.Most existing mathematical models of Notch-Delta signaling are based on a feedback loop between Notch and Delta leading to lateral inhibition of neighboring cells.These models result in a checkerboard spatial pattern whereby

Gene transfer of drug resistance (CTX-R) genes can be used to protect the hematopoietic system from the toxicity of anticancer chemotherapy and this concept recently has been proven by overexpression of a mutant O6-methylguaninemethyltransferase in the hematopoietic system of glioblastoma patients treated with temozolomide.Given its protection capa

Since the approval of rituximab in GRAPE SEED 1997, monoclonal antibodies (mAbs) have become an increasingly important component of therapeutic regimens in oncology.The success of mAbs as a therapeutic class is a result of great strides that have been made in molecular biology and in biotechnology over the past several decades.Currently, there are